Previous studies indicate that T cells, and especially CD8+ T cells perform an essential role in the antitumor immune response, for example, CD8+ T cells induce ferroptosis and pyroptosis resulting in the inhabitation of tumor growth and enhancement of antitumor immunity (Lang et al., 2019; Tang et al., 2020; Zhang et al., 2020); enrichment of CD4+ T cells is associated with good prognosis (Liu et al., 2021). The gene discussed is CD4; the disease is neoplasm.