Most importantly, it has been reported that hsa-miR-4443 is implicated in atrial fibrillation regulation; that is, in atrial fibrillation, hsa-miR-4443 regulates TGF-β1/α-SMA/collagen signaling via targeting THBS1, thereby inhibiting cardiac fibroblast proliferation [43]. The gene discussed is THBS1; the disease is atrial fibrillation.