We indicated that the predicted lncRNA MALAT1-hsa-miR-124-3p/hsa-miR-30d-5p/hsa-miR-101-3p-EZH2 network may play a role in regulating ACE2 expression, whereas the lncRNA MALAT1-hsa-miR-92b-3p/hsa-miR-106b-3p/hsa-miR-25-3p-PTEN network may play a role in the inflammatory response to COVID-19. The gene discussed is ACE2; the disease is COVID-19.