Previous studies have shown that lncRNA MALAT1 can regulate IL-6 and NLRP3 inflammatory cytokines (Paniri and Akhavan-Niaki, 2020), and lncRNA TUG1 plays an important role in the anti-inflammatory response to COVID-19 by blocking IL-6 cytokines (Yang et al., 2021b). The gene discussed is MALAT1; the disease is COVID-19.