By comparing the TB-HIV coinfected individuals with and without IRIS in relation to the allelic frequencies of the 11 Single Nucleotide Polymorphism (SNPs) analyzed in the present study, an increased risk for IRIS was associated with the C/T genotype (ORadj=61.06; P=0.026) and carrier-T (ORadj=61.06; P=0.026) in the AIM2 rs2276405 polymorphism. Here, AIM2 is linked to tuberculosis.