Similar analyses were also conducted according to the different clinical TB presentations (PTB and EPTB) regardless of HIV-1 coinfection (Table 2), and an increased risk for EPTB was associated with carrying the T/T genotype (ORadj=6.76; P=0.026) in the NLPR3 rs4612666 polymorphism or the NLRP3 C-C-T-G-C haplotype (ORadj=4.99; P= 0.017). The gene discussed is NLRP3; the disease is tuberculosis.