By comparing the carriers of the minor frequency allele in individuals with and without TB, CARD8 (rs2043211 and rs6509365), CASP-1 (rs572687), IFI16 (rs1101996), and NLRP3 (rs3806268, rs4612666, rs1539019, and rs10754558) had significant associations with the differences in IL-6 plasma levels; while IFI16 (rs1101996), and NLRP3 (rs3806268, rs1539019, and rs10754558) were significantly associated with differences in IL-33 plasma levels (Table 4). The gene discussed is CARD8; the disease is tuberculosis.