Among PLWH with and without TB, CARD8 (rs2043211 and rs6509365), CASP-1 (rs572687), IFI16 (rs1101996), IL-1β (rs1143634), and NLRP3 (rs3806268, rs4612666, rs1539019, and rs10754558) were significantly associated with differences in IL-6 plasma levels; while CARD8 (rs2043211 and rs6509365), IFI16 (rs1101996), and NLRP3 (rs3806268, rs4612666, rs1539019, and rs10754558) were significantly associated with differences in IL-33 plasma levels (Table 4). The gene discussed is CASP1; the disease is tuberculosis.