Considering the highly inflammatory profiles observed in TB-HIV coinfections, which increase during TB-HIV/IRIS, in the present study, we investigated the distributions of 11 single nucleotide polymorphisms (SNPs) of the major inflammasome pathway genes (e.g., NLRP3, CARD8, AIM2, CASP-1, IFI16, and IL-1β), cytokine levels (e.g., IL-1β, IL-6, IL-18, and IL-33), and their potential influence on the susceptibility to TB and/or HIV-1 as well as on the occurrence of TB-HIV/IRIS. Here, IL1B is linked to tuberculosis.