Here, we showed that the C/T genotype (ORadj=61.06; P=0.026) or carrier-T (ORadj=61.06; P=0.026) in the AIM2 rs2276405 polymorphism was associated with an increased risk of TB-HIV/IRIS in TB-HIV individuals, whereas lower risk IRIS onset was associated with the A/T genotype (ORadj=0.02; P=0.033) or carrier-T (ORadj=0.02; P=0.029) in the CARD8 rs2043211 polymorphism and with the CARD8 T-G haplotype (ORadj=0.07; P= 0.033). Here, AIM2 is linked to tuberculosis.