In brief, one DElncRNA (TRHDE-AS1), two DEmiRNAs (miR-23b and miR-589), and four DEmRNAs (PKIA, SHCBP1, PRSS16 and KIF18A) were found to be prognostic biomarkers in HCC. The gene discussed is PRSS16; the disease is hepatocellular carcinoma.