Seven variants (rs3787946, rs9983330, rs12329760, rs2298659, rs2298661, rs9985159 and rs756036675) within TMPRSS2 were identified to be associated with severe COVID-19 (Andolfo et al., 2021; Monticelli et al., 2021; Villapalos-Garcia et al., 2022). This evidence concerns the gene TMPRSS2 and COVID-19.