For example, Cer(d34:1), which has a higher risk in people with depression (log2(OR) = 1.66, 95% CI: 0.19–3.23, p = 0.0308) and is positively associated with age (β1 = 0.006, p = 0.0120; β2 = 0.006, p = 0.0083), was significantly increased in S2, which indicates that the increase in Cer(d34:1) may be an important signature for geriatric depression (Figure 6C). Here, CBLN1 is linked to major depressive disorder.