Among the genes that contain the RNAm-SNPs identified above, we further found that ASAP2, MRAS, ARHGEF26, MDN1, MTHFSD, SMG6, MYO15A, OSBPL7, AIRE, FTCD and MAPK11 were differentially methylated (seven upregulated and four downregulated; fold change > 2.0, FDR <0.05) in human PBMCs of five CAD cases and five controls (Supplementary Table S4). Here, MTHFSD is linked to coronary artery disorder.