In addition to the genome-wide significant SNP in JCAD, RNAm-SNPs in other important CAD susceptibility genes were also identified, including MRAS and TCF21. These RNAm-SNPs are not genome-wide significant, but they significantly affected the expression levels of MRAS and TCF21, and the expression levels of MRAS and TCF21 were genetically associated with CAD. The gene discussed is TCF21; the disease is coronary artery disorder.