In the CAUSE analysis, which accounted for correlated and uncorrelated horizontal pleiotropic effects, circulating levels of ABO, C5orf38, CD209, CEP57, CTF1, IL3RA, LRRN1, QSOX2, SELE and VIMP were associated with CAD; C5orf38, CD209, CEP57, CTF1, F8, LRRN1 and VIMP levels were found to be associated with AMI (Table 1). The gene discussed is CEP57; the disease is coronary artery disorder.