However, some scholars' studies have shown that THBS1 is involved not only in SCM, but also in atrial fibrillation (59) and tumor invasion (60), therefore, an in-depth exploration of the diagnostic and regulatory ability of THBS1 and its miR-222-3p/THBS1 signaling pathway in SCM, and testing whether THBS1 can be used as a stable biomarker for SCM diagnosis independent of other diseases, will be more home clarify the perspective of this study and provide the best possible de support for early clinical intervention and treatment of SCM. Here, THBS1 is linked to neoplasm.