THBS1 (thrombospondin 1), a member of the thrombospondin family, is expressed in many tissues during embryonic development, but in healthy adults, it is associated with ischemia-reperfusion, tissue remodeling, immune system damage (rheumatoid synovium, glomerulonephritis), atherosclerotic lesions, and high glucose and high-fat induction. The gene discussed is THBS1; the disease is glomerulonephritis.