A remarkable reduction in αIIbβ3 signaling transduction was observed together with the the release of IL-1β in NLRP3 deficient platelets, suggesting NLRP3 inflammasome contribute to the hemostasis and arterial thrombosis with the mediation of IL-1β release and αIIbβ3 signaling (122). The gene discussed is NLRP3; the disease is Arterial thrombosis.