Coincidently, researchers have found that both NAFLD and dementia share 2 important biological risk factors, apolipoprotein E (APO-E) (Yang et al., 2005; Rasmussen, 2016) and adiponectin (ADPN) (Buechler et al., 2011; Rizzo et al., 2020). This evidence concerns the gene APOE and metabolic dysfunction-associated steatotic liver disease.