NFKB1 and Alzheimer disease: Neuroinflammation is an important factor in AD (Parhizkar and Holtzman, 2022), persistent neuroinflammation induces amyloid-beta (Aβ), and neurofibrillary tangle production and death of neurons (Rajesh and Kanneganti, 2022; Weng et al., 2022), activated microglia and astrocytes cause the release of inflammatory factors, such as IL-6, IL-1β, and NF-κB (Bales et al., 1998).