PLIN2 from the PLIN family is characterized by lipid droplet (LD) proteins in adipocytes, which is involved in lipid metabolism and transport, cytoskeletal organization, and intracellular transport and signal transduction; thus, it is implicated in the onset and progression of numerous malignancies, including kidney cell carcinoma and mammary carcinoma [49]. This evidence concerns the gene PLIN1 and breast carcinoma.