Glomerular hyperfiltration, early kidney disease (microalbuminuria: urine albumin-excretion ratio (UAER) 30 to 300 mg/d), overt kidney disease (macroalbuminuria: UAER > 300 mg/d), and ESRD are the stages of disease that are common to both type 1 and type 2 diabetes [4]. The gene discussed is ALB; the disease is type 2 diabetes mellitus.