OGG1 and early-onset autosomal dominant Alzheimer disease: Similarly, the same authors explored the effects of compromised OGG1 activity in a 5XFAD mouse model of Alzheimer’s disease (AD) and found an increase in 8oxo-dG in hippocampal neurons and further deficits in cognition compared to 5XFAD mice with normal OGG1 activity levels [48].