Similar findings were described by Oka et al., who demonstrated that knockout of OGG1 and the nucleoside hydrolase, MTH1, which work collectively to diminish the burden of 8oxo-dG, exacerbated the accumulation of 8oxo-dG in brain microglia of triple-transgenic AD model mice (3xTg-AD-H) and promoted degeneration of the hippocampus [49]. The gene discussed is OGG1; the disease is Alzheimer disease.