Interestingly, the genes for APE1/Ref-1 and OGG1 are hypomethylated in motor cortex and spinal cord motor neurons from ALS patients, suggesting continued expression of the repair proteins and the propensity for DNA repair, thus enhancing the activity of these proteins might be a viable therapeutic strategy for ALS. The gene discussed is OGG1; the disease is amyotrophic lateral sclerosis.