However, a great number of published studies indicated that L1 cell adhesion molecule (L1CAM, CD147) positive exosome-containing Aβ42, T-tau, P-T181-tau, α-syn, and other proteins or ncRNA had higher diagnostic power for neurodegenerative diseases (Shi et al., 2014; Fiandaca et al., 2015; Yang et al., 2018; Jia et al., 2019; Jiang C. et al., 2020; Wang and Zhang, 2020). This evidence concerns the gene MAPT and neurodegenerative disease.