MAPT and neurodegenerative disease: Nevertheless, numerous studies from cell and animal models have shown that pathological proteins such as α-syn and Tau, or the abnormal regulator such as miRNA, lncRNA, and rRNA undergo neuron-to-neuron transmission and partially contribute to the progress of neurodegenerative diseases (Emmanouilidou et al., 2010; Zhou W. et al., 2019; Ruan et al., 2021; Vilcaes et al., 2021).