In addition, some species of bacteria, including Bacteroides caecimuris, Bacteroides xylanisolvens, and Clostridium bolteae, were able to regulate the levels of IL-10+ Tregs and CD8+ T-cells in patients with NAFLD-HCC, suggesting that these bacteria participate in the modulation of adaptive immunity (39). Here, CD8A is linked to hepatocellular carcinoma.