The high expression of HIF-1a and VEGF in the microenvironment of primary liver cancer tissue is closely related to angiogenesis, and they may be the key factors in promoting the formation of new blood vessels in the intratumoral environment and the inflammatory response in the extratumoral environment [20], and Lycium barbarum polysaccharide can inhibit the migration and invasion of liver cancer cells, and its mechanism may be related to the direct inhibition of VEGF [21]. Here, VEGFA is linked to liver cancer.