IDH2 and cancer: Li et al. (2021) found that lncRNA OIP5-AS1 was upregulated in CC tissues and promoted the Warburg effect through induction of the miR-124-5p/IDH2/HIF-1α pathway, leading to proliferation of CC cells. By contrast, studies in RIP1-Tag2 mice showed that intracellular copper expression levels regulate cancer cell proliferation and oxidative phosphorylation through the formation of cytochrome oxidase catalysis (Ishida et al., 2013).