For example, OAS2 could interact with TBXAS1 via PTGS1, PIK3C2B could interact with AREG via EGFR, and CXCR1 could interact with S100A8 via CXCL6. The above results suggest that these proteins play a synergistic role in the regulation of bovine subclinical mastitis. The gene discussed is S100A8; the disease is mastitis.