Hepatic overexpression of LAL using lentivirus in a mouse model of NAFLD led to reduced steatosis and fibrosis, decreased liver inflammation, and decreased serum lipid levels (Li et al., 2021); however, overexpression with an adeno-associated virus in a different mouse model of NAFLD did not attenuate steatosis, and increased liver inflammation (Lopresti et al., 2021). Here, LIPA is linked to steatosis.