LIPA and coronary artery disorder: Potential hypotheses for increased CAD risk with increased LIPA transcript levels could be increased extracellular release of LAL-generated free fatty acids having a pro-inflammatory effect in the plaque intima, increased hydrolysis of CE by exocytosed LAL on LDL retained in the interstitium leading to increased interstitial free cholesterol promoting plaque inflammation, and increased LAL-modified LDL uptake and foam cell formation by intimal macrophages and SMCs.