DNA methylation master regulator UHRF1 and DNA methyltransferase inhibitor zebularine may upregulate LIPA in mesothelioma cells and mouse melanoma, respectively (Fang et al., 2021; Reardon et al., 2021), and histone deacetylase inhibitor voronistat increases LAL protein and activity in fibroblasts (Subramanian et al., 2017). This evidence concerns the gene LIPA and mesothelioma.