The changes in plasma protein levels, especially fibronectin precursor, haptoglobin precursor, coagulation factor XIII A chain, and apolipoprotein C-IV precursor, might affect the progression of DHD in calves by interfering with complement and coagulation cascades, PI3K-Akt signaling pathway, and focal adhesion. This evidence concerns the gene APOC4 and Doyne honeycomb retinal dystrophy.