TOP2A and breast cancer: GO functional analysis revealed that the BC-causing genes were significantly enriched in nuclear division (associated with KGs: TOP2A, AURKA, and BIRC5), organelle fission (associated with KGs: EGFR, AURKA, and BIRC5), and mitotic nuclear division (associated with KGs: MET and BIRC5) (Emmert-Streib et al., 2014; Han et al., 2020; Xiao et al., 2021).