GZMB and age-related macular degeneration: It is important to note that in AMD, over-active mast cells within the choroid represent a major source of GrB within both the choroid and RPE layers, while FECD is primarily a non-inflammatory disorder (Pardo et al., 2007; Parkinson et al., 2015; Wroblewski et al., 2017; Matsubara et al., 2020; Hiroyasu et al., 2021).