GZMB and arthritic joint disease: The normal and pathological functions of GrB have been investigated in a variety of organs and tissues and have implicated GrB in the process of tissue aging, as well as in a variety of age-related diseases (eg. cardiovascular disease, COPD, arthritis) (Hendel et al., 2010; Bao et al., 2018; Qiao et al., 2020; Zeglinski and Granville, 2020).