TGFB1 and Fuchs endothelial corneal dystrophy: Furthermore, treatment with N-acetylcysteine, a thiol-containing antioxidant and radical scavenger, reduced guttae formation, decreased markers of ER stress and significantly improved corneal density in murine models of FECD, suggesting ROS play a role in TGF-β-mediated pathology in FECD (Kim et al., 2014).