GZMB and wet macular degeneration: We speculate that aberrant GrB present within the extracellular space cleaves ECMs such as FN, LAM, and COL which lead to a disorganized Bruch’s membrane, and degrades tight junctional proteins (JAMs and occludin) between RPE cells thereby disrupting the outer blood eye barrier, a key event in choroidal neovascularization in wet AMD.