Early-onset FECD has been ascribed to mutations in the genes COL8A2, TCF4, TCF8, SLC4A11 and AGBL1, while late-onset FECD, which is far more common than early-onset FECD, is a sporadic disease (Liu et al., 2021). This evidence concerns the gene TCF4 and Fuchs endothelial corneal dystrophy.