In total, 14 PDEFRGs (AKR1C1, CD44, CHAC1, DPP4, FANCD2, GLS2, HMGCR, HSPB1, MT1G, NCOA4, SLC7A11, ZEB1, GOT1, and IREB2) were identified (Figure 2(d)) and were found to be significantly associated with the OS of ccRCC patients (all p < 0.05). The gene discussed is IREB2; the disease is nonpapillary renal cell carcinoma.