In total, 14 PDEFRGs (AKR1C1, CD44, CHAC1, DPP4, FANCD2, GLS2, HMGCR, HSPB1, MT1G, NCOA4, SLC7A11, ZEB1, GOT1, and IREB2) were identified (Figure 2(d)) and were found to be significantly associated with the OS of ccRCC patients (all p < 0.05). This evidence concerns the gene HSPB1 and nonpapillary renal cell carcinoma.