Interestingly, an analysis of short nucleotide polymorphisms (SNP) of the ADA gene in a group of 561 MS patients revealed that ADA SNP rs244072 was related to increased CSF levels of TNF-α, IL-5, and RANTES and decreased levels of IL-10 (Bassi et al., 2020). The gene discussed is CCL5; the disease is myeloid sarcoma.