Among 308 patients with colorectal cancer, the serum MMP-2 level in patients with CC genotype at MMP-2 gene−735 (C/T) locus was (139.05 ± 32.06) ng/mL higher than that in patients with CT + TT genotype (119.75 ± 27.44) ng/mL (P < 0.05). The gene discussed is MMP2; the disease is colorectal cancer.