With genotype CC and CT as reference, the adjusted OR (95% CI) of genotype TT was 1.519 (95% CI: 1.061–2.174), which can be considered as an MMP-9 gene −1562 (C/T) locus polymorphism, which is related to the occurrence of colorectal cancer, and TT genotype may increase the risk of colorectal cancer susceptibility. This evidence concerns the gene MMP9 and colorectal cancer.