We found that after 32 weeks of gestation, with the increase of gestational weeks, the Youden index of the ROC curve of each screening program for preeclampsia showed a downward trend, which is similar to the conclusion of previous studies [14–16] that PAPP-A and PLGF are more closely related to the onset of early-onset preeclampsia. Here, PGF is linked to preeclampsia.