The predictive values for the risk of preeclampsia using PAPP-A, PLGF, MAP, and UTPI programs (PAPP-A + PLGF + MAP + UTPI, PAPP-A + PLGF + MAP, PAPP-A + PLGF, PLGF + MAP, PAPP- A) before 32 weeks, 34 weeks, or 37 weeks of gestation were analyzed by the ROC curve. The gene discussed is PGF; the disease is preeclampsia.