Generalized lipodystrophy, autoimmune polyglandular syndrome (97, 98), hypercalcemia (99), low testosterone levels (in the absence of hypophysitis) and a single case of “suspicious” adrenocorticotropic hormone (ACTH)-independent cortisol secretion (in the absence of exogenous cortisol administration) after ICIs’ administration, have also been described (76, 100). This evidence concerns the gene POMC and generalized lipodystrophy.