Before initiating treatment with ICIs, a few initial tests are recommended: thyroid function tests (TSH, free T4, free T3), hypophysis function tests (early morning cortisol levels), fasting glucose, adrenal function tests (ACTH), gonadal function tests (testosterone, luteinizing hormone – LH, and follicle-stimulating hormone – FSH), brain magnetic resonance imaging (MRI) (1, 93, 94). Here, POMC is linked to hypophysitis.