Acts as a component of the retromer cargo-selective complex to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. VPS35 is a key factor in tau phosphorylation and endosomal trafficking (40, 41). VPS35 is involved in the terminal differentiation of neurons, and its defects are risk factors for neurodegenerative diseases (42). The gene discussed is VPS35; the disease is neurodegenerative disease.