May be required for neuronal cell differentiation. Participate in the regulation of RNA splicing, calcium steady-state, voltage gating calcium channel activity. AHNAK is a differentiated protein for normal aging and AD brains and may act as a new biomarker for age-related neurodegenerative changes (27). At the same time, it is involved in a series of physiological activities such as immune regulation, cell structure maintenance, and neuronal excitability (28). Here, AHNAK is linked to Alzheimer disease.