MAPT and neurodegenerative disease: Acts as a component of the retromer cargo-selective complex to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. VPS35 is a key factor in tau phosphorylation and endosomal trafficking (40, 41). VPS35 is involved in the terminal differentiation of neurons, and its defects are risk factors for neurodegenerative diseases (42).