In summary, our experimental results showed that the expression of B7-H3 is upregulated in malignant meningiomas and that the PP2A inhibitor LB-100 can significantly inhibit the proliferation and invasion of malignant meningioma cells while increasing the Tyr701 phosphorylation of STAT1 in malignant meningioma cells. This evidence concerns the gene CD276 and Anaplastic (Malignant) Meningioma.