In summary, our experimental results showed that the expression of B7-H3 is upregulated in malignant meningiomas and that the PP2A inhibitor LB-100 can significantly inhibit the proliferation and invasion of malignant meningioma cells while increasing the Tyr701 phosphorylation of STAT1 in malignant meningioma cells. The gene discussed is STAT1; the disease is Anaplastic (Malignant) Meningioma.