PKD1 and autosomal dominant polycystic kidney disease: In an initial discovery cohort of ADPKD patients with early or late disease, compared with healthy controls, profiling of human urinary exosome miRNA demonstrated that miR-192-5p, miR-194-5p, miR-30a-5p, miR-30d-5p and miR-30e-5p were significantly downregulated in patient urine exosomes, in both human PKD1 cystic kidney tissue, and in murine Pkd1 cystic kidneys.