HMBS and Miyoshi myopathy: In addition to specially developed UPS inhibitors, some commonly used drugs have also been found to be involved in bone metabolism through the UPS system, including thalidomide, lansoprazole, carnosic acid, melatonin, clomipramine, zoledronic acid, and Vitisin A. The immunomodulatory drug (IMiD) thalidomide was originally considered a teratogenic agent but is now used to treat a variety of clinical indications, including MM.