This transcriptional and post-translational regulation of p53 has suggested that PML bodies have a tumor suppressive function, though other p53-independent roles in apoptosis, telomere maintenance, and the DNA damage response have also linked this subnuclear domain to cancer (Guo et al., 2000; Bernardi et al., 2008; Draskovic et al., 2009; Conrad et al., 2016). The gene discussed is TP53; the disease is cancer.