SON may be an on-off regulator of the expression of PTBP1 and PTBP2 in GBM (Kim et al., 2021), and PTBP2 compensates for the absence of Ptbp1 during B cell development in mice (Monzón-Casanova et al., 2020). This evidence concerns the gene PTBP1 and glioblastoma.