When PTBP3 was highly expressed, patients with ACC, LGG, and PAAD had lower survival probability and poorer prognosis (HR > 1, p ≤ 0.05), while patients with KIRC had a longer OS and better prognosis (HR = 0.55, p < 0.001); there was no significant differences observed in patients with KICH and PCPG (p > 0.05) (Figure 4F). Here, PTBP3 is linked to pancreatic adenocarcinoma.