The results revealed that PTBP1 may function through “Cell cycle,” “Human T-cell leukemia virus one infection,” “RNA transport,” “Spliceosome,” “DNA replication,” “Cellular senescence” and “Apoptosis.” PTBP2 may be associated with “Herpes simplex virus one infection” and “Spliceosome” pathways, while PTBP3 may affect tumor progression through “Amyotrophic lateral sclerosis,” “Viral carcinogenesis,” “Cell cycle” and “Homologous recombination” pathways (Supplementary Table S9). This evidence concerns the gene PTBP3 and amyotrophic lateral sclerosis.