Shen et al. explored the difference in cerebrospinal fluid (CSF) or peripheral blood inflammatory markers between patients with AD and MCI and proved the higher level of interleukin-6 (IL-6), interleukin-10 (IL-10), and soluble tumor necrosis factor receptor 1 (sTNFR1) in the brains of patients with AD compared with patients with MCI (28). The gene discussed is TNFRSF1A; the disease is Alzheimer disease.