HNF4A and type 2 diabetes mellitus: miR-122-5p is involved in the inhibition of cardiac fibroblast differentiation induced by apigenin through targeting the transcription factor HIF-1α (Feng et al., 2021); it is regulated by another transcription factor HNF4α in type 2 diabetic mice (Xu et al., 2020), indicating a regulation between miRNA and TF in different diseases.