TPO and autoimmune thrombocytopenic purpura: While the management of acute ITP relies mostly on the administration of intravenous immunoglobulin (IVIG) and corticosteroids (2), the second-line therapeutic options used in patients with persistent and chronic ITP are numerous, and comprehend biologic agents (particularly, the anti-CD20 monoclonal antibody rituximab), thrombopoietin receptor agonists (TPO-RAS), such as eltrombopag and romiplostim, and immunosuppressive agents (mycophenolate mofetil, azathioprine, and others) (2, 3).