CDH5 and Right ventricular hypertrophy: Hypoxia stimulated accumulation of αSMA-positive cells to distal PAs and increased Fulton's index and RVSP in Cdh5(PAC)-CreERT2 mice, suggesting that inhibition of αSMA-positive cell accumulation, right ventricular hypertrophy, and RVSP in p16iΔEC mice is not because of the effects of Cre gene (Supplementary Figures 2B–E).