Gene network analysis of microarray dataset using IPA software reveals that genes from 113 BP GO Term categories containing cellular senescence/SASP genes of normal vs. IPAH patient lungs, which is classified into transcription/gene expression, protein/RNA processing, cell cycle, inflammatory/immune response, cell signaling/signal transduction, or miscellaneous groups, directly or indirectly interacted with TWIST1 (Supplementary Figure 1A). The gene discussed is TWIST1; the disease is idiopathic pulmonary arterial hypertension.