Hypoxia stimulated accumulation of αSMA-positive cells to distal PAs and increased Fulton's index and RVSP in Cdh5(PAC)-CreERT2 mice, suggesting that inhibition of αSMA-positive cell accumulation, right ventricular hypertrophy, and RVSP in p16iΔEC mice is not because of the effects of Cre gene (Supplementary Figures 2B–E). Here, ACTA1 is linked to Right ventricular hypertrophy.