Wang et al. (13) determined that the degree of tumor differentiation, N stage, serum alkaline phosphatase (ALP), lactate dehydrogenase (LDH), CEA, liver and lung metastasis were risk factors for bone metastasis of CRC, and further developed a nomogram to evaluate the risk of bone metastasis in CRC patients. This evidence concerns the gene CEACAM5 and metastasis.