HLA-DRB1*03:01(13.1% vs. 7.8%, P=0.049), DRB1*07:01 (29.1% vs. 20.2%, P=0.0254), DRB1*14:05 (8.3% vs. 4.2%, P=0.05), DRB1*14:54 (9.9% vs. 5.2%, P=0.05), and DQB1*06:01 (25.8% vs. 17.8%, P=0.0353) frequencies were increased in patients with PBC, but did not reach significance after Bonferroni’s correction. Here, HLA-DRB1 is linked to primary biliary cholangitis.