For example, in Ankylosing Spondylitis, variant G in rs30187 (R528) appears to be protective in subjects positive for HLA-B*27, the major susceptibility gene in AS, whereas it is a risk factor for Behçet’s disease in carriers of HLA-B*51, the allele more strongly associated with BD (15). The gene discussed is HLA-B; the disease is Behcet disease.