Decrease level of IL-1β, IL-18, TNF-α, NLRP3, ASC, Procaspase-1, Caspase-1 and GSDMD after LP17 treatment compared to COPD mice.Reduction of bronchial wall thickening and inflammatory cell infiltration after LP17 treatment compared to COPD mice. Here, GSDMD is linked to chronic obstructive pulmonary disease.