The hub genes that can distinguish sepsis from normal samples were identified, which included SCAMP5, DNAJC18, TARDBP, SDF2L1, FBXO2, FBXO6, TBL2, RNF175, PDIA3 and HDGF. Secretory carrier membrane protein 5 (SCAMP5) is an integral membrane protein that was highly expressed in the sepsis samples compared to the controls. The gene discussed is HDGF; the disease is Sepsis.