The study, examining Nrp1 and VEGFR2 interactions in pancreatic ductal adenocarcinoma (PDAC) patients, revealed that the trans configuration of Nrp1 could lead to lack of engagement of endothelial VEGFR2 through possible disrupted signaling pathways, such as in extracellular regulated kinase (ERK). This evidence concerns the gene NRP1 and pancreatic ductal adenocarcinoma.