However, PD-1 was also demonstrated to inhibit Tregs, since PD-L1 blockade could ameliorate PD-1hi Treg depletion and enhance their functions during infection with Toxoplasma gondii (49); and selective deficiency of PD-1 in Tregs augmented their immunosuppressive functions in experimental autoimmune encephalomyelitis (50). This evidence concerns the gene CD274 and infection.