mAbs presented diverse binding activity to SARS-CoV-2 S protein, of which 61.0% showed strong binding activity (EC50< 1 μg/mL); this result suggested that infection with SARS-CoV-2 can effectively stimulate humoral immune response to produce a large number of specific high-affinity mAbs (Figure S2A and Figure 1D). The gene discussed is PROS1; the disease is infection.