The results showed that urinary KIM-1, NGAL, and IL-18 levels in the gout with renal injury group were higher than those in the gout without renal injury group and the control group (P < 0.05), and urinary IL-18 in the gout without renal injury group was higher than that in the control group (P < 0.05). The gene discussed is IL18; the disease is gout.