In the trial referenced above of rhIL-12 in 21 cancer patients, besides IFNγ, TNFα, and IP-10, several other cytokines, including monokine induced by interferon-gamma (MIG), IL-10, and IL-4, were found to be increased in peripheral blood mononuclear cells even when IL-12 was given at very low doses (30 ng/kg) (15). The gene discussed is IFNG; the disease is cancer.