Based on “TCGA Pan-Cancer” cohort, we compared the differences of VCAN expression in human pan-cancer and found that VCAN was widely over-expressed in tumor tissues, such as BRCA, CHOL, COAD, ESCA, GBM, HNSC, KIRC, KIRP, LIHC, LUAD, LUSC, STAD, THCA. This evidence concerns the gene VCAN and cancer.